周磊 讲师
尊龙凯时
Contact Us（联系方式）：
E-mail（邮件）: lei[email protected]
教育背景
2015-2019 重庆大学，遗传学专业，博士学位
2012-2015 重庆大学，生物学专业，硕士学位
2008-2012 河南科技学院，生物技术专业，学士学位
工作经历
2019-至今 尊龙凯时 讲师
研究领域
代谢调控与衰老遗传学。衰老作为多因素驱动的复杂生物学过程，其核心特征表现为代谢稳态的渐进性崩溃。通过秀丽隐杆线虫、家蚕等短生命周期模式生物，结合遗传扰动、多重组学及动态成像技术，系统解析代谢变化如何通过表观遗传修饰、细胞器功能重构和跨组织信号传导等机制驱动衰老进程，为干预衰老相关疾病提供理论依据。
学术贡献
主持国家自然科学基因青年科学基金项目1项；主持中央高校基本科研业务费专项资金项目1项；参研国家自然科学基金项目及省部级项目多项。在 Cell Reports, Plos Genetics, Nature Communications等期刊发表多篇论文。
代表性论文
1) Zhou L, Zhuo H, Jin J, Pu A, Liu Q, Song J, Tong X, Tang H*, Dai F*. Temperature perception by ER UPR promotes preventive innate immunity and longevity. [J]. Cell Reports. 2024, 43(12): 115071.
2) Song J, Li Z, Zhou L, Chen X, Sew WQG, Herranz H, Ye Z, Olsen JV, Li Y, Nygaard M, Christensen K, Tong X, Bohr VA, Rasmussen LJ*, Dai F*. FOXO-regulated OSER1 reduces oxidative stress and extends lifespan in multiple species. [J]. Nature Communications. 2024, 15(1): 7144.
3) Feng, X., Wang, X., Zhou, L., Pang, S., and Tang, H*. The impact of glucose on mitochondria and lifespan is determined by the integrity of proline catabolism in C. elegans. [J]. Journal of Biological Chemistry. 2023, 102881.
4) Zhang J, Li Z, Song J, Zhou L, Chen X, Ge W, Dong T, Luo Y, Mao T, Li Z, Tan D, Rasmussen LJ, Bohr VA, Tong X, Dai F*. Salidroside promotes healthy longevity by interfering with HSP90 activity. [J]. Geroscience. 2023. 46(2):1641-1655.
5) Zhou, L., Tong, H., Tang, H.*, and Pang, S.*. Fatty acid desaturation is essential for C. elegans longevity at high temperature. [J]. Mechanisms of Ageing and Development. 2021, 200, 111586.
6) Zhou, L., He, B., Deng, J., Pang, S.*, and Tang, H*. Histone acetylation promotes long-lasting defense responses and longevity following early life heat stress. [J]. Plos Genetics. 2019, 15, e1008122.